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Sodium Hyaluronate

Sodium hyaluronate is the sodium salt of hyaluronic acid. The EU ingredient database lists it as a humectant and skin conditioning agent, and it is used in serums, creams and other skincare for hyaluronic acid's capacity to hold water. On a label it is a separate name from Hyaluronic Acid, and neither name tells you the size of the molecule a product uses.

What it does

The EU's CosIng database lists two functions for sodium hyaluronate: humectant and skin conditioning.1 The US Cosmetic Ingredient Review describes hyaluronic acid and its sodium and potassium salts as skin conditioning agents, used in cosmetics at concentrations up to 2% at the time of its review.2

Hyaluronic acid is also made in the skin itself. A review of its role in skin ageing calls it the key molecule involved in skin moisture, with a unique capacity to retain water.3 Hyaluronic acid applied in a cosmetic is a separate matter from the hyaluronic acid your skin makes.

Sodium hyaluronate and hyaluronic acid

CosIng gives sodium hyaluronate's chemical name as "Hyaluronic acid, sodium salt".1 Hyaluronic Acid has its own entry, with antistatic, humectant, moisturising and skin conditioning among its functions.4 The Cosmetic Ingredient Review assessed the acid and its salts together.2

A front label that says "hyaluronic acid" may mean either ingredient; the list tells you which name was used. According to the same review, hyaluronic acid is obtained mainly from bacterial fermentation and from rooster combs.2 The name does not say which source a product used.

Molecular weight claims

Hyaluronic acid comes in different molecule sizes, and size can change how far it gets into skin. In a laboratory study that imaged sections of human skin with Raman spectroscopy, low molecular weight hyaluronic acid (20-300 kDa) passed through the stratum corneum, the skin's outermost layer, while high molecular weight hyaluronic acid (1,000-1,400 kDa) did not.5

One study on skin samples does not show what a particular product does on your face. And the ingredient name carries no molecular weight: "low molecular weight" or "multi-weight" on the front of a pack is the brand's description, not something the list can confirm. Some processed forms do have their own names: Hydrolyzed Sodium Hyaluronate, for example, is sodium hyaluronate broken down by hydrolysis.6

What sources say

The Cosmetic Ingredient Review panel found that hyaluronic acid was not a sensitiser in animal studies and that its widespread clinical use, mainly by injection, had been free of significant adverse reactions. It concluded that hyaluronic acid and its sodium and potassium salts are "safe for use in cosmetics as described in the safety assessment".2 That conclusion is about the ingredient as reviewed, not about any particular product.

How it appears on a label

As Sodium Hyaluronate. Related names, such as Hyaluronic Acid, Potassium Hyaluronate and Hydrolyzed Sodium Hyaluronate, are separate ingredients with their own entries.426 A serum may list more than one of them, and each name counts as its own ingredient.

What it does in a formula

Helps attract waterOfficial EU function: Humectant
Keeps skin in good conditionOfficial EU function: Skin conditioning

Sources

  1. European Commission. CosIng entry SODIUM HYALURONATE: INCI name, chemical name and functions, as exported on 9 October 2026. ec.europa.eu Checked 11 October 2026.
  2. Becker LC, et al. Final report of the safety assessment of hyaluronic acid, potassium hyaluronate, and sodium hyaluronate. International Journal of Toxicology 2009;28(4 Suppl):5-67. pubmed.ncbi.nlm.nih.gov Checked 11 October 2026.
  3. Papakonstantinou E, Roth M, Karakiulakis G. Hyaluronic acid: a key molecule in skin aging. Dermato-Endocrinology 2012;4(3):253-8. pubmed.ncbi.nlm.nih.gov Checked 11 October 2026.
  4. European Commission. CosIng entry HYALURONIC ACID: INCI name and functions, as exported on 9 October 2026. ec.europa.eu Checked 11 October 2026.
  5. Essendoubi M, et al. Human skin penetration of hyaluronic acid of different molecular weights as probed by Raman spectroscopy. Skin Research and Technology 2016;22(1):55-62. pubmed.ncbi.nlm.nih.gov Checked 11 October 2026.
  6. European Commission. CosIng entry HYDROLYZED SODIUM HYALURONATE: INCI name, description and functions, as exported on 9 October 2026. ec.europa.eu Checked 11 October 2026.

Written for this site from the sources above and checked against them on 11 October 2026. Not reviewed by a dermatologist or toxicologist, and not medical advice. Spotted something wrong? Tell us.